Molecular Analysis – MTHFR

MTHFR (methylenetetrahydrofolate reductase) is an enzyme involved in the metabolism of folate, a B-vitamin that is important for DNA synthesis and repair. Genetic variations in the MTHFR gene can affect the activity of the enzyme and lead to alterations in folate metabolism, which have been associated with a range of health conditions. AgioMol™ MTHFR - C677T, A1298C tests for the two most common MTHFR variants , C677T and A1298C. These variants are single nucleotide polymorphisms (SNPs) that result in the substitution of one nucleotide for another in the DNA sequence of the MTHFR gene.

The C677T and A1298C variants can lead to reduced MTHFR activity and decreased folate metabolism, which may contribute to increased levels of homocysteine in the blood. Elevated homocysteine levels have been associated with an increased risk of cardiovascular disease, neural tube defects, and other health problems.